中文名：去甲泽拉木醛

CAS：107316-88-1

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Demethylzeylasteral 是一种从 Tripterygium wilfordii Hook F 中分离出来的三萜化合物，具有抗炎、免疫抑制和抗肿瘤活性[1][2] [3][4][5]。 Demethylzeylasteral 可显着缓解动脉粥样硬化 (AS)[5]。 Demethylzeylasteral 通过阻断经典和非经典 TGF-β 信号通路抑制三阴性乳腺癌侵袭[2]。

参考文献：

[1]. Wang Q, et al. Demethylzeylasteral ameliorates inflammation in a rat model of unilateral ureteral obstruction through inhibiting activation of the NF‑κB pathway. Mol Med Rep. 2017 Jul;16(1):373-379.

[2]. Zhao Y, et al. Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells. Cell Death Dis. 2017 Oct 26;8(10):e3133.

[3]. Experimental study of the anti-atherosclerotic effect of demethylzeylasteral. Exp Ther Med. 2017 Jun;13(6):2787-2792.

[4]. Zhang K, et al. Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis. Cell Death Dis. 2018 Oct 10;9(10):1035.

[5]. Li L, et al. Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways. Naunyn Schmiedebergs Arch Pharmacol. 2019 May;392(5):593-603.